Quetiapine Fumarate Syntheses and Its Determination Methods in the Pharmaceutical Dosage Forms, Human Plasma and Urine by RP-HPLC and Other Analytical Techniques: A Review

Rezaei, Mehdi; Ramazani, Ali; Hokmabadi, Fahimeh

doi:10.22034/chemm.2018.60130

Document Type : Review Article

Authors

¹ Department of Chemistry, University of Zanjan, P.O. Box: 45195-313, Zanjan, Iran.

² Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186, Tehran 1496813151, Iran

https://doi.org/10.22034/chemm.2018.60130

Abstract

Background: Quetiapine fumarate is a dibenzothiazepine derivative and it is classified as a second-generation antipsychotic drug that has been established as an effective therapy for schizophrenia and bipolar disorder. These antipsychotics have a low incidence of extrapyramidal side effects and tardive dyskinesi as compared to older antipsychotics. The advantages of the therapeutic profile of quetiapine have led to increasing the use of the clinical practice encouraging the development of new pharmaceutical preparations. Objective: The goal of this work was to recognize the synthesis and analytical deference methods of quetiapine fumarate. Methods: Generally, A precise, specific, rapid and feasible reversed-phase high-performance liquid chromatographic (RP-HPLC), UV spectrophotometric and reversed phase ultra-performance liquid chromatography (RP-UPLC) methods for the determination of an antipsychotic drug quetiapine fumarate in pharmaceuticals, spiked human urine and plasma sample have been developed and collected in this review. The methods also find applications in clinical, biological and pharmacokinetic studies of quetiapine fumarate.

Graphical Abstract

Keywords

Main Subjects

Organic Chemistry

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Chemical Methodologies

Quetiapine Fumarate Syntheses and Its Determination Methods in the Pharmaceutical Dosage Forms, Human Plasma and Urine by RP-HPLC and Other Analytical Techniques: A Review

References

References

Volume 2, Issue 2 - Serial Number 2
April 2018
Pages 141-165

Quetiapine Fumarate Syntheses and Its Determination Methods in the Pharmaceutical Dosage Forms, Human Plasma and Urine by RP-HPLC and Other Analytical Techniques: A Review

References

References

Volume 2, Issue 2 - Serial Number 2April 2018Pages 141-165

Volume 2, Issue 2 - Serial Number 2
April 2018
Pages 141-165